If you've ever migrated a user's workstation from an old domain to a new domain, you know it's not a simple matter of dragging and dropping the contents of the profile directory in Windows Vista and 7 like it was in Windows XP. You have to manually copy selected files and folders and you lose all of the user's preferences.
That is, of course, unless you use the User Profile Wizard from ForensIT. This small, free utility makes it a breeze to migrate user profiles to a new domain.